Vaccines in the treatment of invasive candidiasis
نویسندگان
چکیده
Candida albicans is the most common cause of hematogenously disseminated candidiasis, and this disease is particularly prevalent in immunocompromised patients. The mortality of invasive candidiasis remains 40% to 50% even with the proper treatment with current antifungal drugs. Recently, with the better understanding of host-fungus interactions, notable progress has been made in antifungal vaccine research. Most antifungal vaccines exert protection by inducing either (or both) B-cell and T-cell responses. Here we summarize the current available information on C. albicans vaccines, highlight the obstacles that researchers identified, and offer several suggestions.
منابع مشابه
Immunotherapy and Antifungal Drugs of Candidiasis: Achievements and Challenges
Candida albicans is the most common cause of invasive candidiasis, but in recent years the incidence of infections caused by other species such as Candida Kruzei, Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida lusitania has increased. In the last decade, the treatment methods for invasive candidiasis have changed completely, and a successful treatment depends on the time...
متن کاملInvasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines
Several international and national guidelines have been proposed for the treatment and prevention of invasive candidiasis/candidemia (IC/C) in both neonatal and pediatric patients. This article is a review of the current guidelines, recommendations, and expert panel consensus of a number of associations and conferences on the prevention and management of IC and candidemia in both pediatric and ...
متن کاملBiomarker-guided antifungal stewardship policies for patients with invasive candidiasis
Invasive fungal infections (IFIs) are among the life-threatening issues in patients with impaired immune system. High administration of antifungals in these patients imposes a heavy economic burden on the national health system. In addition, despite the usually expensive antifungal regimens, the mortality rate due to fungal infections is still high, resulting in the loss of hundreds of lives pe...
متن کاملEfficacy of Fluconazole Prophylaxis on Invasive Candidiasis Infection in Extremely Low Birth Weight Neonates
Background: Invasive candidiasis infection is one of the main life-threatening problems for extremely low birth weight (ELBW) neonates who are in the neonatal intensive care unit (NICU). Candidiasis can cause mortality, short-term morbidity, and long-term neurodevelopmental outcome in infected infants who survive. Therefore, since several years ago fluconazole prophylaxis has begun for prematur...
متن کاملImmunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines
Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...
متن کامل